Tight junctions (TJs) are a hallmark of vertebrate epithelial and endothelial tissues, where they play essential canonical and non-canonical functions, such as tissue barrier and cellular signaling, which can be altered in disease. Recent exciting advances driven by new technologies in imaging, structural biology, biophysics and animal models have allowed us to begin to understand structure-function relationships in TJs, from tissue morphogenesis to the design of new therapeutic approaches. This meeting will bring together TJ scientists from around the world to foster the exchange of information, generate new ideas and collaborations, and expand the community of TJ researchers. By sharing complementary expertise and state-of-the art approaches we will deepen our mechanistic understanding TJ biology and its involvement in physiology and pathology.
All conference components, such as the scientific programme, poster exhibition, and social events, are planned as live events. A virtual participation is currently not foreseen.
| Sunday 4th, June | |
|---|---|
| Session 1: Welcome and Keynote Lecture 1 | |
| 14:00 - 19:00 | Check-in and registration |
| 18:00 - 20:00 | Welcome Reception and Dinner |
| 20:00 - 20:10 | Welcome by organizers: Sandra Citi, University of Geneva, Switzerland, Eric Feraille, University of Geneva, Switzerland, Michael Koval, Emory University, USA. |
| 20:10 - 21:00 | Keynote Lecture 1
Asma Nusrat (University of Michigan, USA)Plasticity of the mucosal barrier: Insights into regulation of epithelial tight junctions |
| Monday 5th, June | |
| 07:00 - 08:30 | Breakfast |
| Session 2: Structure and Architecture of Tight Junction Proteins
Chair Mikio Furuse (National Institute for Physiological Sciences, Japan)
|
|
| 08:30 - 09:00 |
Martin Lehmann (Leibniz Institut of Molecular Pharmacology, Germany) Tight & Leaky – What we can learn from molecular nanostructures at Tight Junctions? |
| 09:00 - 09:30 |
Shikha Nangia (Syracuse University, USA) Computational nanoscopy of the tight junction architecture |
| 09:30 - 09:50 | Speaker selected from Abstracts |
| 09:50 - 10:05 | Speaker selected from Abstracts |
| 10:05 - 10:30 | Coffee break |
| 10:30 - 11:00 |
Jörg Piontek (Charité Universtätsmedizin Berlin Clinical Physiology, Germany) Formation of the claudin backbone of tight junction strands including paracellular channels |
| 11:00 - 11:30 |
Luca Maragliano (Università Politecnica delle Marche, Italy) Structural modeling of claudin assemblies at the tight junctions |
| 11:30 - 11:50 | Speaker selected from Abstracts |
| 11:50 - 12:10 | Speaker selected from Abstracts |
| 12:10 - 14:00 | Lunch |
| Session 3: Cell Biology of Tight Junctions
Chair Jerrold Turner (Harvard Medical School, USA)
|
|
| 14:00 - 14:30 |
Mikio Furuse (National Institute for Physiological Sciences, Japan) Regulation of bicellular tight junctions by angulin-1 |
| 14:30 - 15:00 |
Klaus Ebnet (Institute of Medical Biochemistry, Germany) JAM-A: A Multifunctional Adhesion Receptor at Tight Junctions |
| 15:00 - 15:30 |
Karl Matter (University College, UK) Signalling by tight junctions in epithelial morphogenesis |
| 15:30 - 15:45 | Speaker selected from Abstracts |
| 15:45 - 16:15 | Coffee break |
| 16:15 - 16:45 |
Jody Rosenblatt (King’s College, UK) Cell extrusion: an exciting beginning to an end |
| 16:45 - 17:05 | Speaker selected from Abstracts |
| 17:05 - 17:20 | Speaker selected from Abstracts |
| 17:20 - 17:45 | Break |
| 17:45 - 19:30 | Poster session 1 |
| 19:30 - 21:00 | Dinner |
| Tuesday 6th, June | |
| 07:00 - 08:30 | Breakfast |
| Session 4: Tight Junctions in Physiology
Chair Jörg Schulzke (Charité-Universitätsmedizin Berlin, Germany)
|
|
| 08:30 - 09:00 |
Alan Yu (University of Kansas Medical Center, USA) Claudin-2 and renal calcium handling |
| 09:00 - 09:30 |
Dorothée Günzel (Charité-Universitätsmedizin Berlin, Germany) Role of Claudin-10 Splice Variants in Paracellular Transport in Kidney and Underlying HELIX |
| 09:30 - 09:50 | Speaker selected from Abstracts |
| 09:50 - 10:05 | Speaker selected from Abstracts |
| 10:05 - 10:30 | Coffee break |
| 10:30 - 11:00 |
Susan J. Hagen (Harvard Medical School, USA) Tight Junction Claudin18 in Health and Disease |
| 11:00 - 11:30 |
Roland Bücker (Charité-Universitätsmedizin Berlin, Germany) Similarities of Tricellular Tight Junction Defects in Colonocytes during Diarrheal Situations |
| 11:30 - 11:50 | Speaker selected from Abstracts |
| 11:50 - 12:05 | Speaker selected from Abstracts |
| 12:05 - 13:00 | Lunch |
| 13:00 - 18:00 | Excursion |
| Session 5: Keynote Lecture 2 | |
| 18:00 - 18:50 | Keynote Lecture 2
Jerrold Turner (Harvard Medical School, USA)Claudin-2: More than a channel? |
| 19:00 - 20:30 | Dinner |
| Wednesday 7th, June | |
| 07:00 - 08:30 | Breakfast |
| Session 6: Tight Junctions: Pathology, Mechanisms and Therapeutics
Chair Susan J. Hagen (Harvard Medical School, USA)
|
|
| 08:30 - 09:00 |
Michael Koval (Emory University, USA) Impact of alcohol use disorder on lung epithelial barrier function |
| 09:00 - 09:30 |
Susanne Krug (Charité-Universitätsmedizin Berlin, Germany) Role of MarvelD3 in colitis |
| 09:30 - 09:50 | Speaker selected from Abstracts |
| 09:50 - 10:05 | Speaker selected from Abstracts |
| 10:05 - 10:30 | Coffee break |
| 10:30 - 11:00 |
Michael Fromm (Charité-Universitätsmedizin Berlin, Germany) Pathways of water in epithelia |
| 11:00 - 11:30 |
Alf Honigmann (Technische University, Germany) Role of ZO condensation and actin polymerization to form a functional tight junction belt |
| 11:30 - 11:50 | Speaker selected from Abstracts |
| 11:50 - 12:05 | Speaker selected from Abstracts |
| 12:05 - 14:00 | Lunch |
| Session 7: Tight Junctions in Development and Signaling
Chair Jody Rosenblatt (King’s College, UK)
|
|
| 14:00 - 14:30 |
Carl-Phillip Heisenberg (Institute of Science and Technology, Austria) The role of tight junctions in zebrafish epiboly movements |
| 14:30 - 15:00 |
Elif Eroglu (Karolinska Institute, Sweden) Role of tight junctions in the regenerating salamander heart |
| 15:00 - 15:30 |
Ann Miller (University of Michigan, USA) Rho flare-mediated remodeling of tight junctions in developing epithelium |
| 15:30 - 15:45 | Speaker selected from Abstracts |
| 15:45 - 16:15 | Coffee break |
| 16:15 - 16:45 |
Lorenza Gonzalez-Mariscal (CINVESTAV, Mexico) Polyubiquitination and SUMOylation sites modulate ZO-2 stability and tight junction sealing |
| 16:45 - 17:15 |
Junichi Ikenouchi (Kyushu University, Japan) Roles of membrane lipids in tight junction formation |
| 17:15 - 17:45 | Break |
| 17:45 - 19:00 | Poster session 2 |
| 19:00 - 20:30 | Dinner |
| Thursday 8th, June | |
| 07:00 - 08:30 | Breakfast |
| Session 8: Keynote 3; Tight junctions and the cytoskeleton
Chair Sandra Citi (University of Geneva, Switzerland)
|
|
| 08:30 - 09:20 | Keynote Lecture 3
Sachiko Tsukita (Teikyo University, Japan)Tight Junctions and Its Associating Apical Cytoskeleton Define the Epithelial Barrier |
| 09:20 - 09:50 |
Rocio Lopez-Posadas (University of Erlangen, Germany) Targeting prenylated Rho GTPases for epithelial restoration in gastrointestinal diseases |
| 09:50 - 09:55 | Speaker selected from Abstracts |
| 09:55 - 10:20 | Coffee break |
| 10:20 - 10:35 | Speaker selected from Abstracts |
| 10:35 - 11:05 |
Maria Balda (University College London, UK) Tight junction-associated Rho GEFs in retinal function and disease |
| 11:05 - 11:30 | Award of Poster Prizes |
| 11:30 - 12:00 | Concluding remarks |
| 12:00 - | Departure |
As of May 2023, the WHO has determined that COVID-19 no longer constitutes a public health emergency of international concern. There are no restrictions for accessing the event, facilities and venue, there is no mask requirement at the event or at public spaces, including transport, and there is no test or quarantine requirement for entering Switzerland.
Check here (https://travelcheck.admin.ch/home) for possible conditions applying for your country or (find up-to-date details about entering Switzerland ).
You are responsible for applying for a visa for entry into Switzerland should it be necessary based on your nationality.
Practical information on how to reach the hotel from Geneva Airport by public transportation and train schedules are in the downloadable PDF documents.
Practical_info_TJ2023.pdf TRAIN_SCHEDULES_TJMEETING2023.pdf
